Because you like Winry Rockbell in Fullmetal Alchemist
Yuri is living in the afterlife, which takes the form of a high school where no one dies. But if you follow the school's rules and live a "normal" life you vanish. See them in Angel Beats!.
From secret organizations to alien attacks, Kyon's life has been one weird, unexplainable thing happening after another. See them in The Melancholy of Haruhi Suzumiya.
The "runt" of his biker gang, Tetsuo Shima grapples with a perpetual inferiority complex. See them in Akira.
Wise beyond his years, Ashitaka is a dutiful young prince who respects the balance of life. See them in Princess Mononoke.
Empathetic Nausicaa embraces all forms of life, even those that might scare other people. See them in Nausicaa of the Valley of the Wind.
Though bold and pure of heart, Utena Tenjou has a fairytale vision of the world that can make her oblivious to its darkness. See them in Revolutionary Girl Utena.
While he might be too cool for school, Soul isn't too cool to do the right thing. See them in Soul Eater.
For Celty Sturluson, it's rather upsetting to be the only headless girl in a city filled with full-bodied humans. See them in Durarara!!.
Underneath Fakir's sarcastic exterior is a loyal friend. But his loyalty borders on being possessive of his friends. See them in Princess Tutu.
An alien, a time-traveler, and an esper are following Haruhi Suzumiya, who – unknown to herself – is a near-omnipotent reality warper. See them in The Melancholy of Haruhi Suzumiya.
Trying to get through school without being a burden to anyone, Tohru Honda stays cheerful despite her difficulties. See them in Fruits Basket.