Because you like Rue in Princess Tutu
The vampire that killed Zero Kiryu's family also infected him, and he starts to crave blood, much to his horror. See them in Vampire Knight.
What Mako Mankanshoku lacks in common sense, she makes up for in sheer optimism and force of personality. See them in Kill la Kill.
When dealing with a half-demon partner and a world of violence, Kagome Higurashi has plenty of chances for her true courage to shine. See them in Inuyasha.
With the loyalty and pluckiness of a puppy, Nana Komatsu is a hopeless romantic. See them in Nana.
Yuki Cross is a cheerful, funny, bold young woman with hidden insecurities. See them in Vampire Knight.
Gou Matsuoka offers to help as manager of a swim team, believing that they're the only ones who can help her brother. See them in Free! Iwatobi Swim Club.
A vampire hunter, Integra Hellsing doesn't tolerate failure, least of all her own. See them in Hellsing.
Impassive, overly literal, and a little short on people skills, Angel dedicates her life to enforcing the rules. See them in Angel Beats!.
Courteous, dangerous, and powerful, Kaname Kuran controls an entire court of vampires. Very, very pretty vampires. See them in Vampire Knight.
Trying to get through school without being a burden to anyone, Tohru Honda stays cheerful despite her difficulties. See them in Fruits Basket.
Reclusive, quiet, and seemingly emotionless, Lain Iwakura feels like an outsider in her hyper-connected world. See them in Serial Experiments Lain.
Vash might act like a carefree, peace-loving goof, but it's not wise to underestimate this "Humanoid Typhoon." See them in Trigun.