Because you like Einar Wegener/Lili Elbe in The Danish Girl
M. Bison is a diabolical megalomaniac hell-bent on dominating the world. See them in Street Fighter.
Susanna Kaysen is an aspiring writer, despairing young woman who struggles with suicidal thoughts. See them in Girl, Interrupted.
Dustin Henderson doesn't let the bullies get to him. He's secure in who he is and that his friends have his back. See them in Stranger Things.
Anya Jenkins has a real harsh bark to go with her demonic bite. See them in Buffy the Vampire Slayer.
Ciri had a princess upbringing, and some of the facts of common people's lives are a mystery to her. See them in The Witcher.
A Silurian lizard woman, Madame Vastra has a penchant for puzzles and interspecies romance. See them in Doctor Who.
Arizona Robbins loves being a pediatric surgeon, and the cute orthopedic surgeon downstairs makes coming into work worth her while. See them in Grey's Anatomy.
A kind, sensitive medical intern doing the best he can, George O'Malley sometimes struggles to keep up. See them in Grey's Anatomy.
High school is Hell, so Allison Reynolds spends her time giving herself tattoos with ballpoint pens and shaking dandruff out of her hair. See them in The Breakfast Club.
John Yossarian is trapped in irony as he must be insane to leave the war but if he does try to leave, he'll be deemed sane and will be forced to stay, See them in Catch-22.
Nadia Vulvokov is a no-nonsense broad with a dark sense of humor and a flippant attitude. See them in Russian Doll.