Because you like Marlena Rosenbluth in Water for Elephants
Trying to get through school without being a burden to anyone, Tohru Honda stays cheerful despite her difficulties. See them in Fruits Basket.
His superiority complex coupled with his bitter desire for revenge makes Vegeta a formidable foe. See them in Dragon Ball Z.
Daria Morgendorffer is so defensive that she actively works to make people dislike her so that she don't feel bad when they do. See them in Daria.
Blaine Anderson is a put-together prep school boy with the voice of an angel. See them in Glee.
Irene Adler has to use both her brains and her body to survive. Luckily, she's usually the most brilliant person in the room. See them in Sherlock.
Yuri is living in the afterlife, which takes the form of a high school where no one dies. But if you follow the school's rules and live a "normal" life you vanish. See them in Angel Beats!.
The last war left his economy devastated, and now Germany is engaged in another war and stuck with two barely trained allies for help. See them in Axis Powers Hetalia.
A wildly brilliant detective, Sherlock Holmes can figure out everything except how to interact with other human beings. See them in Sherlock.
Tony Stark's interests include cocktails, beautiful women, particle physics, and saving the world. See them in Marvel Cinematic Universe.
A fight every now and then makes Dante's life a little more interesting. See them in Devil May Cry.
Don't mess with Mickey Milkovich unless you want to see the wrong side of one of his many guns. See them in Shameless.
Even with the world on the line, Bayonetta is an Umbra Witch who maintains a biting sense of humor. See them in Bayonetta.