Because you like Moira in The Handmaid's Tale
Marie Antoinette may be a fun-loving queen who has it all, but her husband doesn't know how to have sex, and an angry mob wants to cut off her head. See them in Marie Antoinette.
Mavis Dracula's interests are anything black, scream cheese, and flying around. See them in Hotel Transylvania.
For somebody who won't answer questions, the enigmatic C.C. sure asks a lot of them. See them in Code Geass.
Faith has a chip on her shoulder and a stake in her hand to slay vampires in her town. See them in Buffy the Vampire Slayer.
Bad-ass Rayne has sworn her life to finding and destroying her vampire dad, Kagan, and killing as many other vampires as she can in the bargain. See them in BloodRayne .
The Sohma family is just plain cursed, and Yuki Sohma has to learn to live with it – or so he thinks. See them in Fruits Basket.
John Yossarian is trapped in irony as he must be insane to leave the war but if he does try to leave, he'll be deemed sane and will be forced to stay, See them in Catch-22.
Toby Cavanaugh has trouble avoiding being manipulated. See them in Pretty Little Liars.
Meat Boy tenaciously throws himself into danger, and when he fails, he immediately gets back up and tries again. See them in Super Meat Boy.
Give in to the dark side with vampire Lestat; it's more fun. See them in Interview with the Vampire: The Vampire Chronicles.
For the sake of science, Kurisu Makise will persevere no matter how deep into the dark secrets of the world she finds herself. See them in Steins;Gate.