Because you like Francine Smith in American Dad!
CIA operative Carrie Mathison is on a self-assigned mission to follow a lead, whether it be the truth or just her delusions playing tricks. See them in Homeland.
The brilliant Mona Vanderwaal is proof that undergoing an "extreme makeover" isn't always a good thing. See them in Pretty Little Liars.
Jane Smith is a stone-cold killer, but you would never know it from looking at her. See them in Mr. & Mrs. Smith.
Philip J. Fry accidentally cryogenically froze himself for a millennium. See them in Futurama.
Izzie Stevens is a model-turned-med student who can do it all, even if people underestimate her. See them in Grey's Anatomy.
Felicity Smoak is a brilliant hacker who nonetheless becomes tongue-tied in front of attractive men. See them in DC Extended Universe.
Velma Dinkley is all about getting results, not taking credit. She is the unsung hero of Mystery Inc. See them in Scooby-Doo.
A karate master/rocket scientist/squirrel, Sandy Cheeks is the only one who can clean up the other resident's messes in Bikini Bottom. See them in SpongeBob SquarePants.
Andy Dwyer might not be completely literate, but he makes up for it in spirit. See them in Parks and Recreation.
Charismatic, sociopathic, and dramatic, Charlie Bronson wants nothing more than to be famous. See them in Bronson.