Because you like Sheldon J. Plankton in SpongeBob SquarePants
Kyoya Ootori is possibly the only person who could reasonably go from VP of a school club to ruling the world. See them in Ouran High School Host Club.
Walter White's knowledge of chemistry allows him to cook astoundingly pure meth, leading to a rapid – albeit tumultuous – rise in the criminal drug world. See them in Breaking Bad.
For somebody who won't answer questions, the enigmatic C.C. sure asks a lot of them. See them in Code Geass.
Pro tip: the psych ward is not the best place to find a mentor like Lisa Rowe. See them in Girl, Interrupted.
The Sohma family is just plain cursed, and Yuki Sohma has to learn to live with it – or so he thinks. See them in Fruits Basket.
World domination and Superman's demise are next on Lex Luthor's to-do list. See them in DC Extended Universe.
Gru's more misunderstood than evil, and if he'd rule over the world like he takes care of his three daughters, we'd be in good hands. See them in Despicable Me.
Elizabeth Harmon loves to win at chess, but competitive pressure and her past are taking a toll. See them in The Queen's Gambit.
A Berlin-based locksmith by day, Wolfgang Bogdanow is a world-class thief by night. He can also see out of other people's eyes, but that's a different issue. See them in Sense8.
CIA operative Carrie Mathison is on a self-assigned mission to follow a lead, whether it be the truth or just her delusions playing tricks. See them in Homeland.
A loyal dinosaur, Yoshi loves both saving the day and chowing down on a good meal. See them in Super Mario Bros..