Because you like Seth in Superbad

Milo Thatch is an enthusiastic researcher without cynicism. See them in Atlantis: The Lost Empire.

Emma Woodhouse knows what's best for everyone else. Just don't try to tell her what to do. See them in Emma.

Firo Prochainezo is swept up in a world of mysterious women, alchemists, and rumors of a wine that makes it drinkers immortal. See them in Baccano!.

Wanderer is a Soul, a parasite sent into a host to take over their body, extracting information from them and colonizing their species. See them in The Host.

Clarice Starling is patiently working with one serial killer to stop another. See them in The Silence of the Lambs.

Tifa Lockhart is part mother hen, part martial arts bad-ass. See them in Final Fantasy Series.

A brilliant graduate student in Italy for "research," Oliver has other things on his mind: flirting, swimming, and dancing. See them in Call Me by Your Name.

Jack Skellington is a nightmare-man with a soft heart and smooth voice. See them in The Nightmare Before Christmas.

Knuckles the Echidna is a 16-year-old red echidna (aka a spiny anteater) and guardian of the ancient Master Emerald. See them in Sonic the Hedgehog.

A gentle alchemist who is soul-bound to a giant suit of armor, Alphonse Elric is growing into the responsibility handed to him. See them in Fullmetal Alchemist.

Sometimes being a supportive girlfriend like Ophelia doesn't work out too well. See them in Hamlet.

Foggy Nelson is a principled small-time lawyer fighting for fellow little guys. See them in Marvel Cinematic Universe.