Because you like Stewie Griffin in Family Guy
An alien, a time-traveler, and an esper are following Haruhi Suzumiya, who – unknown to herself – is a near-omnipotent reality warper. See them in The Melancholy of Haruhi Suzumiya.
After several hundred years of shutting himself out from the rest of the world, Japan's not used to dealing with nations, See them in Axis Powers Hetalia.
After becoming accepted into the group of popular girls, Tracy Freeland has turned from a sweet and reserved teenager into a monster. See them in thirteen.
The only constant in Night Vale is Cecil's hypnotic voice. See them in Welcome to Night Vale.
Love Quinn is a trained chef and excellent girlfriend, but she's hiding something dark. And bloody. See them in You.
You'll never get Alaska Young. And that's the whole point. See them in Looking for Alaska.
Yuri is living in the afterlife, which takes the form of a high school where no one dies. But if you follow the school's rules and live a "normal" life you vanish. See them in Angel Beats!.
Freelance writer Diane is dating a dog and writing a memoir of a horse. See them in Bojack Horseman.
Amy March blends her naturally artistic spirit with a sense of practicality. See them in Little Women.
Gou Matsuoka offers to help as manager of a swim team, believing that they're the only ones who can help her brother. See them in Free! Iwatobi Swim Club.
Guillermo is the best servant a vampire could ask for. For years now. Not that he's counting. See them in What We Do In The Shadows.
Carolos has perfect hair, a lab coat, and a constant readiness to do science. See them in Welcome to Night Vale.